Description

tert-Butyl 3-((5-Bromo-3-Formylpyridin-2-Yloxy)-Methyl)Pyrrolidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound matters because it serves as a sophisticated building block for synthesizing complex molecules, particularly in the creation of kinase inhibitors and other targeted therapeutics. Pharmaceutical R&D teams and fine chemical manufacturers need this specific intermediate to enable efficient and scalable synthetic routes for novel active pharmaceutical ingredients (APIs). Its defined structure, featuring both bromo and formyl functional groups, offers versatile points for further chemical elaboration.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of kinase inhibitors and other small-molecule drug candidates.
• Chemical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• API Synthesis: Integral component in multi-step synthetic routes for producing complex Active Pharmaceutical Ingredients (APIs).
• Bioconjugation & Probe Development: The aldehyde group enables its use in creating fluorescent probes or bioconjugates for biochemical assays.
• Custom Synthesis: Serves as a starting material for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.
• Academic Research: Utilized in university and institutional labs for developing new synthetic methodologies and exploring novel chemical space.

Basic Information

Product Name	tert-Butyl 3-((5-Bromo-3-Formylpyridin-2-Yloxy)-Methyl)Pyrrolidine-1-Carboxylate
CAS No.	1203499-20-0
Molecular Formula	C16H21BrN2O4
Molecular Weight	385.26 g/mol
Synonyms	1-Boc-3-((5-bromo-3-formylpyridin-2-yloxy)methyl)pyrrolidine; tert-Butyl 3-[(5-bromo-3-formyl-2-pyridinyloxy)methyl]-1-pyrrolidinecarboxylate; 2-Pyridinecarboxaldehyde, 5-bromo-3-[[(3S)-1-(1,1-dimethylethoxy)carbonyl]-3-pyrrolidinyl]methoxy]-; 1-(tert-Butoxycarbonyl)-3-((5-bromo-3-formylpyridin-2-yloxy)methyl)pyrrolidine; Boc-3-((5-Br-3-CHO-pyridin-2-yloxy)methyl)pyrrolidine; 1203499-20-0; 5-Bromo-3-((1-Boc-pyrrolidin-3-yl)methoxy)picolinaldehyde
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-((5-Bromo-3-Formylpyridin-2-Yloxy)-Methyl)Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot to support your quality assurance and regulatory documentation needs. We adhere to cGMP principles where applicable to meet the stringent requirements of the pharmaceutical industry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.