Description

4-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-3-Iodopyridine is a sophisticated, high-purity chemical intermediate featuring a protected hydroxyl group and a reactive iodine substituent on a pyridine-pyrrolidine scaffold. This compound is engineered to provide exceptional stability and precise reactivity for complex multi-step synthesis, particularly in pharmaceutical research and development. It is primarily sought after by pharmaceutical companies, contract research organizations (CROs), and advanced fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and other bioactive molecules.

Application

This advanced intermediate is designed for use in complex organic synthesis, particularly in the pharmaceutical sector. Key application areas include:

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel drug candidates, especially those targeting the central nervous system (CNS) and other therapeutic areas.
• Cross-Coupling Reactions: The iodine atom serves as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to introduce complex molecular fragments.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Protected Precursor Synthesis: The tert-butyldimethylsilyl (TBDMS) protecting group allows for selective deprotection in the presence of other sensitive functional groups during synthesis.
• Ligand and Catalyst Development: Potential use in the development of novel chiral ligands or organocatalysts due to its pyrrolidine nitrogen and protected chiral center.

Basic Information

Product Name	4-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-3-Iodopyridine
CAS No.	1203498-95-6
Molecular Formula	C16H27IN2OSi
Molecular Weight	418.39 g/mol
Synonyms	3-Iodo-4-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-pyrrolidinyl]pyridine; 4-(3-(((tert-Butyldimethylsilyl)oxy)methyl)pyrrolidin-1-yl)-3-iodopyridine; 3-Iodo-4-(3-((tert-butyldimethylsilyloxy)methyl)pyrrolidin-1-yl)pyridine; TBDMS-protected 3-iodo-4-pyrrolidinylpyridine derivative; N-(3-Iodopyridin-4-yl)-3-((tert-butyldimethylsilyloxy)methyl)pyrrolidine; CAS 1203498-95-6
EINECS	Contact for details

Quality Control

Our production of 4-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-3-Iodopyridine adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research and development applications. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to verify chemical identity and meet the high-purity standards required for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be sensitive to fluoride/strong alkali conditions. Keep away from incompatible materials and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.