Description

2-Chloro-5-Methyl-3-(Trimethylsilyl)Pyridine is a high-purity organosilicon-substituted pyridine derivative, serving as a versatile and valuable building block in advanced organic synthesis. Its unique structure, combining a halogenated pyridine core with a silyl protecting group, makes it a critical intermediate for constructing complex molecules with precise functionality. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), especially for drugs targeting the central nervous system or possessing complex heterocyclic architectures.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the pyridine and silyl groups contribute to biological activity and metabolic stability.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis, such as cross-coupling reactions, due to its modifiable halogen and silyl sites.
• Material Science Research: Employed in the development of organic electronic materials, including organic light-emitting diodes (OLEDs) and semiconductors, where its electronic properties can be fine-tuned.
• Chemical Biology Probes: Useful for creating tagged molecules or probes for studying biological systems, leveraging the silyl group for further functionalization or as a protecting group strategy.
• Custom Synthesis and Scale-Up: Supplied for contract research organizations (CROs) and chemical development teams requiring reliable, high-quality building blocks for custom synthesis projects from milligram to kilogram scale.

Basic Information

Product Name	2-Chloro-5-Methyl-3-(Trimethylsilyl)Pyridine
CAS No.	1203498-92-3
Molecular Formula	C9H14ClNSi
Molecular Weight	199.75 g/mol
Synonyms	3-(Trimethylsilyl)-2-chloro-5-methylpyridine; 2-Chloro-5-methyl-3-(trimethylsilyl)pyridine; Pyridine, 2-chloro-5-methyl-3-(trimethylsilyl)-; 2-Chloro-5-methyl-3-trimethylsilylpyridine; 2-Chloro-3-trimethylsilyl-5-methylpyridine; TMS-protected 2-chloro-5-methylpyridine
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Methyl-3-(Trimethylsilyl)Pyridine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically ≥97% (by HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support development and production needs with specifications that can meet the stringent requirements of cGMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.