Description

4-Benzyl 1-tert-Butyl 2-(Aminomethyl)Piperazine-1,4-Dicarboxylate is a high-value, protected piperazine derivative featuring orthogonal amine-protecting groups. This compound serves as a critical versatile building block for the synthesis of complex molecules, particularly in pharmaceutical research and development. It is essential for medicinal chemists and process development scientists working on new drug candidates, especially those targeting central nervous system (CNS) disorders, infectious diseases, and oncology.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its modifiable amine and carboxylate functionalities.
• Peptidomimetic Synthesis: Serves as a constrained scaffold to mimic peptide structures, enhancing metabolic stability and bioavailability.
• Ligand and Catalyst Development: Employed in the creation of chiral ligands for asymmetric synthesis or as a precursor for metal-chelating agents.
• Chemical Biology Probes: Utilized in the synthesis of tool compounds and probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A starting material for the custom synthesis of more complex, proprietary compounds for clients in the life sciences sector.

Basic Information

Item	Detail
Product Name	4-Benzyl 1-tert-Butyl 2-(Aminomethyl)Piperazine-1,4-Dicarboxylate
CAS No.	1202800-72-3
Molecular Formula	C18H27N3O4
Molecular Weight	349.43 g/mol
Synonyms	1-Boc-4-Cbz-2-(aminomethyl)piperazine; tert-Butyl 4-benzyl 2-(aminomethyl)piperazine-1,4-dicarboxylate; 2-(Aminomethyl)-1-(tert-butoxycarbonyl)-4-(benzyloxycarbonyl)piperazine; 1-N-Boc-4-N-Cbz-2-(aminomethyl)piperazine; 2-Aminomethyl-1,4-bis(alkoxycarbonyl)piperazine derivative; N-Boc-N'-Cbz-2-(aminomethyl)piperazine; 1202800-72-3; 4-Benzyl 1-tert-butyl piperazine-1,4-dicarboxylate-2-ylmethanamine
EINECS	Contact for details

Quality Control

Our 4-Benzyl 1-tert-Butyl 2-(Aminomethyl)Piperazine-1,4-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and structural identity, meeting the stringent requirements for research and development use. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles by HPLC, NMR, and MS are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere or in a desiccator for long-term storage. Typical recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.