Description

3-Azetidinecarboxylic Acid, 1-[[3-Fluoro-4-[5-(1-Phenylcyclopropyl)Thiazolo[5,4-B]Pyridin-2-Yl]Phenyl]Methyl]- is a sophisticated heterocyclic building block designed for advanced pharmaceutical and agrochemical research. This compound is valued for its unique molecular architecture, which incorporates an azetidinecarboxylic acid core fused with a thiazolopyridine and phenylcyclopropyl moiety, offering a versatile scaffold for drug discovery. It is primarily utilized by medicinal chemists and R&D teams in the pharmaceutical industry for the synthesis of novel active pharmaceutical ingredients (APIs) and as a key intermediate in the development of targeted therapies.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new therapeutic agents.
• Protease Inhibitor Development: Serves as a core scaffold or precursor in the design of protease inhibitors due to its constrained azetidine ring.
• Agrochemical Synthesis: Potential intermediate for creating new generation pesticides and herbicides with specific modes of action.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of complex molecules under cGMP or research-grade conditions.

Basic Information

Product Name	3-Azetidinecarboxylic Acid, 1-[[3-Fluoro-4-[5-(1-Phenylcyclopropyl)Thiazolo[5,4-B]Pyridin-2-Yl]Phenyl]Methyl]-
CAS No.	1202073-26-4
Molecular Formula	C27H22FN3O2S
Molecular Weight	471.55 g/mol
Synonyms	1-[(3-Fluoro-4-{5-[1-phenylcyclopropyl]thiazolo[5,4-b]pyridin-2-yl}phenyl)methyl]azetidine-3-carboxylic acid; 1-[[3-Fluoro-4-[5-(1-Phenylcyclopropyl)Thiazolo[5,4-B]Pyridin-2-Yl]Phenyl]Methyl]azetidine-3-carboxylic Acid; AZD-8835 Intermediate; Thiazolopyridine Azetidine Derivative; CAS 1202073-26-4
EINECS	Contact for details

Quality Control

Our production of 3-Azetidinecarboxylic Acid, 1-[[3-Fluoro-4-[5-(1-Phenylcyclopropyl)Thiazolo[5,4-B]Pyridin-2-Yl]Phenyl]Methyl]- adheres to stringent quality protocols to ensure batch-to-batch consistency and purity suitable for research and development. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support development under quality systems appropriate for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is likely moisture-sensitive (hygroscopic); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.