Description

Tofogliflozin is a potent and highly selective sodium-glucose cotransporter 2 (SGLT2) inhibitor. This active pharmaceutical ingredient (API) is critical for the development and manufacture of innovative anti-diabetic medications. It is primarily required by pharmaceutical companies and research institutions focused on metabolic disorders. Tofogliflozin CAS NO 1201913-82-7 represents a key therapeutic agent in the management of type 2 diabetes.

Application

• Pharmaceutical API: Core active ingredient in the formulation of SGLT2 inhibitor class anti-diabetic drugs.
• Clinical Research: Used in preclinical and clinical studies for investigating new diabetes treatments and combination therapies.
• Drug Development: Serves as a reference standard and building block in the synthesis of novel therapeutic compounds targeting glucose reabsorption.
• Metabolic Disorder Studies: Employed in biochemical research to study SGLT2 function and renal glucose handling mechanisms.
• Finished Dosage Form Manufacturing: Integrated into the production of oral solid dosage forms such as tablets and capsules.

Basic Information

Item	Details
Product Name	Tofogliflozin
CAS No.	1201913-82-7
Molecular Formula	C₂₂H₂₅FO₆·C₄H₄O₄
Molecular Weight	540.52 g/mol (hemifumarate)
Synonyms	Tofogliflozin hemifumarate; CSG452; 1-Chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)benzyl]benzene hemifumarate; (1S)-1,5-Anhydro-1-[3-(1-benzothiophen-2-ylmethyl)-4-fluorophenyl]-D-glucitol hemifumarate; Apleway; Deberza
EINECS	Contact for details

Quality Control

Our Tofogliflozin is manufactured under strict quality management systems. It undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use, including identification, assay, and impurity profile analysis. A Certificate of Analysis (COA) is provided with each batch, detailing specifications and results. Our quality commitment aligns with ICH guidelines and current Good Manufacturing Practices (cGMP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.