Description

1-Piperazinecarboxylic Acid, 4-(6-Chloro-2,3-Dihydro-1-Oxo-1H-Pyrrolo[3,4-C]Pyridin-4-Yl)-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery and development. This compound serves as a critical building block for the synthesis of novel therapeutic agents, particularly in the fields of oncology and central nervous system (CNS) disorders. It is primarily sought after by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and production of active pharmaceutical ingredients (APIs) targeting specific disease pathways.
• Oncology Drug Development: Used in the synthesis of investigational compounds designed as kinase inhibitors or other targeted cancer therapies.
• CNS Drug Research: Serves as a building block for novel compounds being studied for neurological and psychiatric conditions.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale synthesis during drug development phases.
• Custom Synthesis: Utilized by CDMOs for the contract manufacturing of proprietary drug candidates for client companies.
• Academic Research: Used in university and institutional labs for medicinal chemistry programs and biological activity studies.

Basic Information

Product Name	1-Piperazinecarboxylic Acid, 4-(6-Chloro-2,3-Dihydro-1-Oxo-1H-Pyrrolo[3,4-C]Pyridin-4-Yl)-, 1,1-Dimethylethyl Ester
CAS No.	1201676-04-1
Molecular Formula	C16H19ClN4O3
Molecular Weight	350.80 g/mol
Synonyms	tert-Butyl 4-(6-chloro-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-4-yl)piperazine-1-carboxylate; 4-(6-Chloro-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-4-yl)piperazine-1-carboxylic acid tert-butyl ester; 6-Chloro-4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one; BOC-Protected Chloropyrrolopyridine Piperazine Intermediate
EINECS	Contact for details

Quality Control

Our 1-Piperazinecarboxylic Acid, 4-(6-Chloro-2,3-Dihydro-1-Oxo-1H-Pyrrolo[3,4-C]Pyridin-4-Yl)-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.