Description

Methyl 5-Tosyl-5H-Pyrrolo[2,3-B]Pyrazine-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a key building block in the synthesis of complex heterocyclic molecules, enabling the creation of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers focused on oncology, kinase inhibitors, and other targeted therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, particularly those targeting protein kinases.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• API Development: Serves as a building block for the final construction of Active Pharmaceutical Ingredients (APIs) in pilot and commercial-scale production.
• Biochemical Tool Compound: Employed in biochemical assays and as a reference standard for analytical method development and validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.

Basic Information

Product Name	Methyl 5-Tosyl-5H-Pyrrolo[2,3-B]Pyrazine-2-Carboxylate
CAS No.	1201188-66-0
Molecular Formula	C15H13N3O4S
Molecular Weight	331.35 g/mol
Synonyms	5H-Pyrrolo[2,3-b]pyrazine-2-carboxylic acid, 5-[(4-methylphenyl)sulfonyl]-, methyl ester; Methyl 5-(p-tolylsulfonyl)-5H-pyrrolo[2,3-b]pyrazine-2-carboxylate; 5-Tosyl-5H-pyrrolo[2,3-b]pyrazine-2-carboxylic acid methyl ester; Methyl 5-(4-methylbenzenesulfonyl)-5H-pyrrolo[2,3-b]pyrazine-2-carboxylate; CAS 1201188-66-0
EINECS	Contact for details

Quality Control

Our Methyl 5-Tosyl-5H-Pyrrolo[2,3-B]Pyrazine-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.