Description

5-[(4-Methylphenyl)Sulfonyl]-5H-Pyrrolo[2,3-B]Pyrazin-2-Amine is a high-purity, advanced pharmaceutical intermediate belonging to the pyrrolopyrazine class of heterocyclic compounds. This compound is critical for research and development in medicinal chemistry, serving as a key building block for the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing small molecule drugs targeting various disease pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for drug discovery programs.
• Kinase Inhibitor Development: Core scaffold for research into novel kinase inhibitors due to its privileged pyrrolopyrazine structure.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• Biochemical Probe Synthesis: Employed in creating tool compounds for studying biological pathways and target validation.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs engaged in custom synthesis and process development.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and drug design.

Basic Information

Product Name	5-[(4-Methylphenyl)Sulfonyl]-5H-Pyrrolo[2,3-B]Pyrazin-2-Amine
CAS No.	1201187-46-3
Molecular Formula	C13H12N4O2S
Molecular Weight	288.32 g/mol
Synonyms	5-[(4-Methylphenyl)sulfonyl]-5H-pyrrolo[2,3-b]pyrazin-2-amine; 5-(p-Tolylsulfonyl)-5H-pyrrolo[2,3-b]pyrazin-2-amine; 2-Amino-5-[(4-methylphenyl)sulfonyl]-5H-pyrrolo[2,3-b]pyrazine; 5H-Pyrrolo[2,3-b]pyrazin-2-amine, 5-[(4-methylphenyl)sulfonyl]-; CAS 1201187-46-3; Pyrrolopyrazine sulfonamide derivative; Tolylsulfonyl pyrrolopyrazinamine
EINECS	Contact for details

Quality Control

Our 5-[(4-Methylphenyl)Sulfonyl]-5H-Pyrrolo[2,3-B]Pyrazin-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.