Description

tert-Butyl 5-Tosyl-5H-Pyrrolo[2,3-B]Pyrazin-2-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate belonging to the pyrrolopyrazine class of heterocyclic compounds. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of complex, biologically active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly in oncology and targeted drug discovery.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of potential drug candidates, especially kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes during drug discovery.
• Oncology Drug Development: Serves as a precursor in the creation of targeted therapies designed to interfere with specific cancer cell pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.
• Bioconjugation & Probe Synthesis: The reactive functional groups make it suitable for creating chemical probes for biochemical assays.
• Academic Research: Employed in university and institutional labs for exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	tert-Butyl 5-Tosyl-5H-Pyrrolo[2,3-B]Pyrazin-2-Ylcarbamate
CAS No.	1201187-44-1
Molecular Formula	C18H20N4O4S
Molecular Weight	388.44 g/mol
Synonyms	tert-Butyl (5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)carbamate; 2-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-[(4-methylphenyl)sulfonyl]-5H-pyrrolo[2,3-b]pyrazine; Boc-Protected 5-Tosyl-5H-pyrrolo[2,3-b]pyrazin-2-amine; 5H-Pyrrolo[2,3-b]pyrazin-2-amine, N-[(1,1-dimethylethoxy)carbonyl]-5-[(4-methylphenyl)sulfonyl]-; tert-Butyl 5-(p-Tolylsulfonyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate; Boc-5-Tosyl-5H-pyrrolo[2,3-b]pyrazin-2-amine; CAS 1201187-44-1
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Tosyl-5H-Pyrrolo[2,3-B]Pyrazin-2-Ylcarbamate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP (current Good Manufacturing Practice) guidelines where applicable, and our analytical methods, including HPLC, NMR, and MS, are validated to provide reliable specifications for our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.