Description

1H-Pyrrolo[2,3-B]Pyridine, 2-Bromo-1-[(4-Methylphenyl)Sulfonyl]- is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. This compound is critical for research and development in medicinal chemistry, particularly for constructing complex heterocyclic scaffolds. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of kinase inhibitors and other targeted therapeutic agents.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for drug discovery programs.
• Agrochemical Development: Serves as a precursor in the synthesis of novel herbicides and fungicides.
• Organic Synthesis: A versatile reagent for constructing complex pyrrolopyridine-based heterocycles via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig).
• Chemical Biology: Used in the development of molecular probes and tool compounds for biological target validation.
• Material Science Research: Potential precursor for organic electronic materials and ligands in catalysis.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 2-Bromo-1-[(4-Methylphenyl)Sulfonyl]-
CAS No.	1198416-32-8
Molecular Formula	C14H11BrN2O2S
Molecular Weight	351.22 g/mol
Synonyms	2-Bromo-1-tosyl-1H-pyrrolo[2,3-b]pyridine; 2-Bromo-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine; 2-Bromo-1-(p-toluenesulfonyl)-1H-pyrrolo[2,3-b]pyridine; 2-Bromo-1H-pyrrolo[2,3-b]pyridine-1-sulfonic acid 4-methylphenyl ester; 2-Bromo-1-(4-methylbenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1-Tosyl-2-bromo-1H-pyrrolo[2,3-b]pyridine; 2-Bromo-1-(p-tolylsulfonyl)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We implement strict analytical controls, including HPLC, GC, and NMR, to guarantee high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. Our quality management system supports development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.