Description

tert-Butyl 4-(2,2,2-Trifluoro-Acetamido)Piperazin-1-Carboxylate CAS NO 1198286-22-4 is a high-purity, protected piperazine derivative featuring a trifluoroacetamide group, serving as a critical synthetic intermediate in advanced organic chemistry. Its primary value lies in providing a versatile, reactive scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working in drug discovery, agrochemical synthesis, and the production of fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, central nervous system (CNS) agents, and antiviral compounds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce the piperazine moiety with a protected amine handle.
• Agrochemical Synthesis: Intermediate in the production of novel pesticides and herbicides, leveraging the stability and reactivity of the trifluoroacetamide group.
• Peptidomimetics & Bioactive Molecule Design: Serves as a constrained dipeptide isostere or a conformational restriction element in designing peptide-like drug candidates.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and labeled compounds for target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects requiring specific, high-value nitrogen heterocycles for client-specific applications.

Basic Information

Product Name	tert-Butyl 4-(2,2,2-Trifluoro-Acetamido)Piperazin-1-Carboxylate
CAS No.	1198286-22-4
Molecular Formula	C11H18F3N3O3
Molecular Weight	297.27 g/mol
Synonyms	1-Boc-4-(2,2,2-trifluoroacetamido)piperazine; tert-Butyl 4-[(trifluoroacetyl)amino]piperidine-1-carboxylate; N-(1-Boc-piperazin-4-yl)-2,2,2-trifluoroacetamide; 1-(tert-Butoxycarbonyl)-4-(2,2,2-trifluoroacetamido)piperazine; 4-(Trifluoroacetylamino)-1-piperazinecarboxylic acid tert-butyl ester; Boc-4-(TFA-amino)piperazine; 1198286-22-4; Piperazine, 4-[(trifluoroacetyl)amino]-, 1-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(2,2,2-Trifluoro-Acetamido)Piperazin-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring the material is suitable for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.