Description

4,4-Difluoro-3,3-Dimethylpiperidine Hydrochloride is a high-purity, fluorinated piperidine derivative offered as a stable hydrochloride salt. This compound serves as a critical advanced pharmaceutical intermediate (API Intermediate) and a versatile building block for medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Used in drug discovery programs for structure-activity relationship (SAR) studies and lead optimization, leveraging the unique properties of the difluoro and dimethyl groups.
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides, fungicides, and insecticides, where the fluorine atoms can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Employed in the creation of novel ligands for asymmetric catalysis or as a structural component in organocatalysts.
• Chemical Biology Probes: Useful for synthesizing labeled compounds or probes for studying biological mechanisms and target engagement.

Basic Information

Product Name	4,4-Difluoro-3,3-Dimethylpiperidine Hydrochloride
CAS No.	1198285-09-4
Molecular Formula	C7H14ClF2N
Molecular Weight	185.64 g/mol
Synonyms	4,4-Difluoro-3,3-dimethylpiperidine HCl; 3,3-Dimethyl-4,4-difluoropiperidine hydrochloride; Piperidine, 4,4-difluoro-3,3-dimethyl-, hydrochloride; 4,4-Difluoro-3,3-dimethylpiperidinium chloride
EINECS	Contact for details

Quality Control

Our 4,4-Difluoro-3,3-Dimethylpiperidine Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the material under an inert atmosphere or in a desiccator for long-term storage. Recommended storage temperature: 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.