Description

6-(Difluoromethoxy)Nicotinonitrile is a high-value, fluorinated pyridine derivative serving as a critical synthetic intermediate in advanced organic chemistry. Its unique difluoromethoxy-substituted nicotinonitrile scaffold is essential for constructing complex molecules with tailored biological and physical properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance metabolic stability and bioavailability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic electronic materials.
• Ligand Synthesis: Employed in medicinal chemistry for constructing complex heterocyclic ligands used in catalysis and molecular recognition.
• Fluorine Chemistry Studies: A valuable substrate for investigating novel fluorination reactions and the effects of fluorine substitution on molecular properties.

Basic Information

Product Name	6-(Difluoromethoxy)Nicotinonitrile
CAS No.	1198103-42-2
Molecular Formula	C7H4F2N2O
Molecular Weight	170.12 g/mol
Synonyms	6-(Difluoromethoxy)-3-cyanopyridine; 3-Cyano-6-(difluoromethoxy)pyridine; Nicotinonitrile, 6-(difluoromethoxy)-; Pyridine, 3-cyano-6-(difluoromethoxy)-; 2-(Difluoromethoxy)-5-cyanopyridine; 5-Cyano-2-(difluoromethoxy)pyridine
EINECS	Contact for details

Quality Control

Our 6-(Difluoromethoxy)Nicotinonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.