Description

2-Chloro-4-Iodo-5-Methylpyridine is a high-purity halogenated pyridine derivative, a key building block in advanced organic synthesis. This compound matters for its unique reactivity profile, offering versatile sites for further functionalization via cross-coupling and nucleophilic substitution reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the pyridine core for bioactivity.
• Material Science Research: Acts as a monomer or functional unit in the creation of specialized ligands, catalysts, and organic electronic materials.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Nucleophilic Substitution: The chlorine atom provides a site for displacement with various nucleophiles, enabling rapid diversification of the molecular scaffold.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein interactions.

Basic Information

Product Name	2-Chloro-4-Iodo-5-Methylpyridine
CAS No.	1197957-18-8
Molecular Formula	C6H5ClIN
Molecular Weight	253.47 g/mol
Synonyms	5-Methyl-2-chloro-4-iodopyridine; 4-Iodo-2-chloro-5-methylpyridine; 2-Chloro-4-iodo-5-picoline; 2-Chloro-4-iodo-5-methylpyridine; Pyridine, 2-chloro-4-iodo-5-methyl-; 1197957-18-8
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Iodo-5-Methylpyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.