Description

2-Bromo-6-(Trifluoromethyl)Pyrazine is a high-value, multi-functional heterocyclic building block. This compound is critical for introducing both bromine and trifluoromethyl functional groups into complex molecular architectures, enabling precise structural modifications. It is primarily sought after by R&D and process chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for designing functionalized pyrazine-based ligands, organic semiconductors, and liquid crystal materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi, Stille) to form carbon-carbon bonds.
• Fluorine Chemistry: Essential for incorporating the metabolically stable trifluoromethyl group into target molecules, a common strategy in modern medicinal chemistry.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs and research organizations for custom synthesis and library production for high-throughput screening.

Basic Information

Product Name	2-Bromo-6-(Trifluoromethyl)Pyrazine
CAS No.	1197237-95-8
Molecular Formula	C5H2BrF3N2
Molecular Weight	226.98 g/mol
Synonyms	2-Bromo-6-(trifluoromethyl)pyrazine; 6-Bromo-2-(trifluoromethyl)pyrazine; 2-(Trifluoromethyl)-6-bromopyrazine; Pyrazine, 2-bromo-6-(trifluoromethyl)-; 1197237-95-8; 2-Bromo-6-trifluoromethylpyrazine
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-6-(Trifluoromethyl)Pyrazine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure consistency and purity for your critical synthesis work. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, and NMR are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.