Description

Propargyl-Peg8-N3 is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal propargyl group and an azide (N3) group, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry. This compound is essential for creating stable, well-defined bioconjugates and functionalized materials with precise control over architecture and spacing. It is primarily utilized by researchers and manufacturers in pharmaceutical development, bioconjugation, materials science, and nanotechnology for applications such as drug delivery system assembly, surface functionalization, and hydrogel synthesis.

Application

• Bioconjugation and ADC Development: Site-specific conjugation of antibodies, proteins, peptides, or small molecule drugs to create antibody-drug conjugates (ADCs) and other therapeutic constructs.
• PEGylation and Linker Chemistry: Serving as a hydrophilic, flexible spacer to improve solubility, reduce immunogenicity, and prolong circulation time of conjugated biomolecules.
• Materials Surface Functionalization: Modifying nanoparticles, quantum dots, biosensors, and other material surfaces with bioactive ligands or probes via click chemistry.
• Polymer and Hydrogel Synthesis: Cross-linking agent for creating functionalized PEG-based hydrogels and polymers with tailored properties for tissue engineering and drug release.
• Diagnostic Reagent Preparation: Conjugation of fluorescent dyes, imaging agents, or affinity tags to targeting molecules for in vitro and in vivo diagnostics.
• Chemical Biology Probes: Tool compound for labeling and studying biological processes through bioorthogonal click chemistry reactions in live cells.

Basic Information

Product Name	Propargyl-Peg8-N3
CAS No.	1196733-06-8
Molecular Formula	C27H51N3O11
Molecular Weight	593.71 g/mol
Synonyms	Azido-PEG8-propargyl; Propargyl-PEG8-azide; N3-PEG8-Propargyl; 1-Azido-3,6,9,12,15,18,21,24-octaoxaheptacos-26-yn-27-ol; Propargyl-PEG8-N3; 26-Azido-3,6,9,12,15,18,21,24-octaoxahexacos-1-yn-27-ol; PEG8 azide propargyl ether; Heterobifunctional PEG linker, Propargyl and Azide terminated
EINECS	Contact for details

Quality Control

Our Propargyl-Peg8-N3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, identity, and functional group integrity. Certificates of Analysis (COA) detailing specifications such as purity (by HPLC/NMR), functional group substitution, and absence of critical impurities are provided to guarantee batch-to-batch consistency for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Analysis	Azide & Propargyl content conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.