Description

2-Chloro-3-Hydroxy-5-Trifluoromethylpyridine is a high-value, multi-functional pyridine derivative that serves as a critical building block in advanced chemical synthesis. Its unique trifluoromethyl and chloro-hydroxy substitution pattern makes it an indispensable intermediate for creating molecules with enhanced biological activity and physicochemical properties. This compound is primarily sought after by R&D and process development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, where the trifluoromethyl group often improves lipophilicity and metabolic stability.
• Material Science Research: Used in the synthesis of specialized ligands, metal-organic frameworks (MOFs), and functional polymers.
• Chemical Biology Probes: Serves as a core structure for developing fluorescent tags and molecular probes for diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A pivotal starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-Chloro-3-Hydroxy-5-Trifluoromethylpyridine
CAS No.	1196153-98-6
Molecular Formula	C6H3ClF3NO
Molecular Weight	197.54 g/mol
Synonyms	5-(Trifluoromethyl)-2-chloro-3-pyridinol; 2-Chloro-3-hydroxy-5-(trifluoromethyl)pyridine; 3-Hydroxy-2-chloro-5-trifluoromethylpyridine; 2-Chloro-5-(trifluoromethyl)pyridin-3-ol; 2-Chloro-3-pyridinol, 5-(trifluoromethyl)-; 3-Pyridinol, 2-chloro-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-3-Hydroxy-5-Trifluoromethylpyridine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is sensitive to strong alkalis and fluorides; keep away from incompatible materials. Keep the container tightly sealed in a dry environment to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.