Description

2-Methyl-6-Trifluoromethyl-Piperazine is a specialized fluorinated piperazine derivative, a high-value building block prized for its unique structural and electronic properties. Its core value lies in enabling the synthesis of novel compounds with enhanced metabolic stability, lipophilicity, and bioavailability. This intermediate is critically needed by pharmaceutical and agrochemical R&D teams for developing new active ingredients, particularly in the areas of CNS drugs, antiviral agents, and advanced crop protection chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel Active Pharmaceutical Ingredients (APIs), especially for central nervous system (CNS) and antiviral therapeutics.
• Agrochemical Synthesis: Used in creating advanced fungicides, herbicides, and insecticides where the trifluoromethyl group confers improved biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for nitrogen-containing ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated polymers and specialty materials with unique surface properties.
• Chemical Biology Probes: Useful for designing molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-Methyl-6-Trifluoromethyl-Piperazine
CAS No.	1196153-83-9
Molecular Formula	C6H11F3N2
Molecular Weight	168.16 g/mol
Synonyms	2-Methyl-6-(trifluoromethyl)piperazine; 6-(Trifluoromethyl)-2-methylpiperazine; 2-Methyl-6-trifluoromethylpiperazine; 1-Methyl-4-(trifluoromethyl)piperazine (isomer); 2-Methyl-6-trifluoromethyl-piperazine; 2-Methyl-6-(trifluoromethyl)-1,4-diazacyclohexane; 2-Methyl-6-trifluoromethylpiperazine hydrochloride (salt form); TFMP derivative
EINECS	Contact for details

Quality Control

Our 2-Methyl-6-Trifluoromethyl-Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.