Description

2-Bromo-5-Fluoropyridin-4-Ol is a halogenated pyridine derivative that serves as a versatile and high-value building block in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the fluorine atom can enhance biological activity and metabolic stability.
• Material Science Research: Employed as a precursor for creating functionalized ligands, organic electronic materials, and liquid crystals.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags for studying biological systems and diagnostic applications.

Basic Information

Product Name	2-Bromo-5-Fluoropyridin-4-Ol
CAS No.	1196152-88-1
Molecular Formula	C5H3BrFNO
Molecular Weight	191.99 g/mol
Synonyms	4-Hydroxy-2-bromo-5-fluoropyridine; 5-Fluoro-2-bromopyridin-4-ol; 2-Bromo-5-fluoro-4-hydroxypyridine; 2-Bromo-5-fluoro-4-pyridinol; 4-Pyridinol, 2-bromo-5-fluoro-; 2-Bromo-5-fluoropyridin-4-ol; 2-Bromo-5-fluoro-4(1H)-pyridinone (tautomer)
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Fluoropyridin-4-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques. Our quality commitment aligns with the standards required for cGMP and ISO-guided production environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry, inert conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.