Description

Ethyl 4-Bromo-6-(Trifluoromethyl)Nicotinate is a high-value, multi-functional chemical building block essential for advanced organic synthesis. Its core value lies in the strategic combination of a bromo-substituent and a trifluoromethyl group on the nicotinate core, enabling precise molecular construction and the introduction of desirable physicochemical properties. This compound is critically needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by material scientists exploring functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory pathways.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a versatile scaffold for constructing specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the creation of organic electronic materials, liquid crystals, and advanced polymers due to its unique electronic properties imparted by the halogen and fluorine atoms.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	Ethyl 4-Bromo-6-(Trifluoromethyl)Nicotinate
CAS No.	1196146-14-1
Molecular Formula	C9H7BrF3NO2
Molecular Weight	298.06 g/mol
Synonyms	4-Bromo-6-(trifluoromethyl)nicotinic acid ethyl ester; Ethyl 4-bromo-6-(trifluoromethyl)pyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 4-bromo-6-(trifluoromethyl)-, ethyl ester; 4-Bromo-6-trifluoromethyl-nicotinic acid ethyl ester; Ethyl 4-bromo-6-trifluoromethylnicotinate
EINECS	Contact for details

Quality Control

Our Ethyl 4-Bromo-6-(Trifluoromethyl)Nicotinate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC for residual solvent analysis, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.