Description

n-{3-[5-(2-Chloro-4-Pyrimidinyl)-2-(1,1-Diethylethyl)-1,3-Thiazol-4-Yl]-2-Fluoraphenyl}-2,6-Difluorobenzenesulfonamide CAS NO 1195768-23-0 is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant value in medicinal chemistry research and development, particularly for its role as a key building block in the synthesis of targeted therapeutic agents. It is primarily needed by R&D laboratories and pharmaceutical manufacturers engaged in the discovery of novel small-molecule drugs, especially within oncology and other disease areas requiring precise molecular scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of investigational new drugs (INDs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Development: Particularly relevant for the research and synthesis of potential kinase inhibitors, given its pyrimidine and thiazole motifs.
• Biochemical Tool Compound: May be utilized in vitro to study biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.
• Academic Research: Employed in university and institutional labs for advanced organic synthesis and chemical biology studies.

Basic Information

Product Name	n-{3-[5-(2-Chloro-4-Pyrimidinyl)-2-(1,1-Diethylethyl)-1,3-Thiazol-4-Yl]-2-Fluoraphenyl}-2,6-Difluorobenzenesulfonamide
CAS No.	1195768-23-0
Molecular Formula	C25H20ClF3N4O2S2
Molecular Weight	556.03 g/mol
Synonyms	N-[3-[5-(2-Chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide; 1195768-23-0; Tert-butyl 4-(3-((2,6-difluorophenyl)sulfonamido)-2-fluorophenyl)thiazole-5-carboxylate derivative; Benzenesulfonamide, N-[3-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-; A kinase inhibitor intermediate; Sulfonamide-thiazole-pyrimidine derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research applications. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as purity, identity, and impurity profiles. While typically supplied as a research-grade chemical, synthesis can be aligned with cGMP guidelines for projects requiring higher regulatory standards. All analytical data is generated using validated methods including HPLC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed under an inert atmosphere if specified. For long-term storage, consider freezing at -20°C. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.