Description

(2S)-2,3-Dimethyl-2-Piperazin-1-Ylbutanoic Acid Dihydrochloride is a high-purity chiral piperazine derivative, primarily utilized as a critical pharmaceutical intermediate. Its value lies in enabling the synthesis of complex, biologically active molecules with precise stereochemistry, which is essential for modern drug discovery and development. This compound is particularly needed by research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in the development of new therapeutic agents, especially within medicinal chemistry and process chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates.
• Process Chemistry Development: Serves as a starting material or intermediate in scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Chiral Synthesis: Exploits its defined (2S) stereochemistry to introduce chirality into target molecules, a critical factor for drug efficacy and safety.
• Custom Synthesis & Contract Manufacturing: Supplied to partners requiring specialized, high-quality intermediates for proprietary synthesis projects.
• Chemical Reference Standard: Can be used as an analytical standard for quality control and method development in API manufacturing.

Basic Information

Product Name	(2S)-2,3-Dimethyl-2-Piperazin-1-Ylbutanoic Acid Dihydrochloride
CAS No.	1192887-66-3
Molecular Formula	C10H21N2O2 • 2HCl
Molecular Weight	281.21 g/mol (Free base: 201.29 g/mol)
Synonyms	(2S)-2,3-Dimethyl-2-(piperazin-1-yl)butanoic acid dihydrochloride; (S)-2,3-Dimethyl-2-(piperazin-1-yl)butanoic acid dihydrochloride; 2,3-Dimethyl-2-piperazin-1-ylbutanoic acid dihydrochloride (S-enantiomer); UNII-6Q3J0W3W8F; Butanoic acid, 2,3-dimethyl-2-(1-piperazinyl)-, (2S)-, dihydrochloride; 6Q3J0W3W8F; (S)-2,3-Dimethyl-2-piperazin-1-yl-butyric acid dihydrochloride
EINECS	Contact for details

Quality Control

Our (2S)-2,3-Dimethyl-2-Piperazin-1-Ylbutanoic Acid Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP intermediate applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.