Description

5-tert-Butoxypyrazin-2-Ylboronic Acid Pinacol Ester is a high-value, organoboron building block used in advanced synthetic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern pharmaceutical and agrochemical development. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-purity intermediates for constructing complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing functionalized pyrazine cores.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific heterocyclic structures.
• Material Science Research: Employed in the creation of organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a critical boronic ester partner for coupling with various aryl or heteroaryl halides to form biaryl or heterobiaryl linkages.
• Chemical Biology & Medicinal Chemistry: Facilitates the rapid exploration of structure-activity relationships (SAR) by allowing efficient diversification of core pyrazine structures.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations for custom synthesis and scale-up projects requiring specialized boronic acid derivatives.

Basic Information

Product Name	5-tert-Butoxypyrazin-2-Ylboronic Acid Pinacol Ester
CAS No.	1192838-57-5
Molecular Formula	C14H23BN2O3
Molecular Weight	278.16 g/mol
Synonyms	5-(tert-Butoxy)pyrazin-2-ylboronic acid pinacol ester; 2-(5-tert-Butoxypyrazin-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-tert-Butoxy-2-pyrazinylboronic acid pinacol ester; 5-tert-Butoxypyrazine-2-boronic acid pinacol ester; tert-Butyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazin-5-yl ether; Boronic acid, B-[5-[(1,1-dimethylethyl)oxy]-2-pyrazinyl]-, 1,1-dimethylethyl ester; 5-tert-Butoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazine
EINECS	Contact for details

Quality Control

Our 5-tert-Butoxypyrazin-2-Ylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive coupling reactions. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical and advanced chemical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.