Description

tert-Butyl (5-Ethynylpyridin-3-Yl)Carbamate is a high-purity, advanced pharmaceutical intermediate featuring a pyridine core with both ethynyl and carbamate functional groups. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of targeted small molecule therapeutics. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its reactive ethynyl group for click chemistry and other coupling reactions.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Boc) group provides a base-labile protecting group for amines in multi-step synthetic sequences.
• Bioconjugation & Probe Development: The alkyne moiety enables efficient conjugation to azide-containing biomolecules or fluorescent tags via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Chemical Library Synthesis: Employed in the combinatorial and parallel synthesis of diverse compound libraries for high-throughput screening.
• Process Chemistry & Scale-Up: Serves as a defined starting material or intermediate in the development of robust, scalable GMP manufacturing routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	tert-Butyl (5-Ethynylpyridin-3-Yl)Carbamate
CAS No.	1192472-59-5
Molecular Formula	C12H14N2O2
Molecular Weight	218.25 g/mol
Synonyms	3-((tert-Butoxycarbonyl)amino)-5-ethynylpyridine; 5-Ethynyl-3-pyridinylcarbamic acid 1,1-dimethylethyl ester; tert-Butyl N-(5-ethynyl-3-pyridinyl)carbamate; BOC-5-Ethynyl-3-aminopyridine; 5-Ethynylpyridin-3-amine BOC-protected; N-Boc-5-ethynylpyridin-3-amine
EINECS	Contact for details

Quality Control

Our tert-Butyl (5-Ethynylpyridin-3-Yl)Carbamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting cGMP and ISO standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.