Description

(R)-1-(tert-Butoxycarbonyl)-5-Oxopiperazine-2-Carboxylic Acid is a high-purity, chiral piperazine derivative serving as a critical building block in advanced organic synthesis. This compound matters because it provides a protected, enantiomerically pure scaffold essential for constructing complex molecules with precise stereochemistry. It is primarily needed by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), particularly in protease inhibitor and other novel therapeutic classes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, especially protease inhibitors and other small molecule therapeutics.
• Peptidomimetic Research: Used to introduce constrained piperazine motifs into peptide backbones to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to construct complex, stereodefined heterocycles.
• Chemical Biology & Proteomics: Utilized in the design and synthesis of activity-based probes and enzyme inhibitors for target validation studies.
• Custom Synthesis & Contract Manufacturing: Serves as a specialized building block for custom synthesis projects at CROs and CDMOs.
• Academic Research: Used in university and institutional labs for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	(R)-1-(tert-Butoxycarbonyl)-5-Oxopiperazine-2-Carboxylic Acid
CAS No.	1191885-45-6
Molecular Formula	C10H16N2O5
Molecular Weight	244.25 g/mol
Synonyms	(R)-1-Boc-5-oxopiperazine-2-carboxylic acid; (R)-1-(tert-Butoxycarbonyl)-2-piperazinecarboxylic acid, 5-oxo-; (R)-5-Oxo-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid; Boc-D-5-oxopipecolic acid (related analog); (2R)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-5-oxopiperazine-2-carboxylic acid; (R)-N-Boc-5-oxopiperazine-2-carboxylic acid; Chiral Boc-protected oxopiperazinecarboxylic acid
EINECS	Contact for details

Quality Control

Our (R)-1-(tert-Butoxycarbonyl)-5-Oxopiperazine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial identification tests, to ensure compliance with high-purity standards for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.