Description

3-Iodo-4-(Trifluoromethyl)-7-Azaindole is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. Its unique structure, featuring both an iodine substituent and a trifluoromethyl group on an azaindole core, makes it a critical intermediate for creating novel compounds with tailored properties. This product is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of kinase inhibitors, receptor antagonists, and other small-molecule drug candidates targeting various diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the biological activity-modifying effects of the trifluoromethyl and halogen groups.
• Material Science: Serves as a precursor for organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters or charge transport materials, due to its conjugated azaindole system.
• Cross-Coupling Reactions: The iodine atom provides an excellent handle for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Buchwald-Hartwig) to construct complex molecular architectures.
• Fluorine Chemistry: Acts as a valuable scaffold for introducing fluorine-containing motifs into molecules to enhance metabolic stability, lipophilicity, and binding affinity.
• Chemical Biology: Utilized as a probe or tag in medicinal chemistry for structure-activity relationship (SAR) studies and bio-conjugation.

Basic Information

Product Name	3-Iodo-4-(Trifluoromethyl)-7-Azaindole
CAS No.	1190320-56-9
Molecular Formula	C8H4F3IN2
Molecular Weight	312.03 g/mol
Synonyms	4-(Trifluoromethyl)-3-iodo-1H-pyrrolo[2,3-b]pyridine; 3-Iodo-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 3-iodo-4-(trifluoromethyl)-; 7-Azaindole, 3-iodo-4-(trifluoromethyl)-; 3-Iodo-4-trifluoromethyl-7-azaindole
EINECS	Contact for details

Quality Control

Our 3-Iodo-4-(Trifluoromethyl)-7-Azaindole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications in GMP (Good Manufacturing Practice) environments and research requiring the highest material standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive). Keep away from strong acids/bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white or light yellow crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 97.0% (Area Percent)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.