Description

1H-Pyrrolo[2,3-B]Pyridine-4-Carboxylic Acid, 6-Chloro-2,3-Dihydro-2-Oxo-, Methyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is critical for research and development in medicinal chemistry, serving as a key building block for synthesizing novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical companies and contract research organizations (CROs) engaged in the development of targeted therapies, particularly in oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex drug candidates, particularly kinase inhibitors and other targeted small molecules.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents with improved efficacy and safety profiles.
• API Synthesis: Serves as a core scaffold for constructing the final active pharmaceutical ingredient in advanced therapeutic pipelines.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and cGMP production of clinical trial materials.
• Biochemical Research: Utilized as a reference standard or probe compound in biochemical assays to study specific biological pathways and protein interactions.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-4-Carboxylic Acid, 6-Chloro-2,3-Dihydro-2-Oxo-, Methyl Ester
CAS No.	1190312-76-5
Molecular Formula	C9H7ClN2O3
Molecular Weight	226.62 g/mol
Synonyms	6-Chloro-2,3-dihydro-2-oxo-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid methyl ester; Methyl 6-chloro-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-4-carboxylate; 6-Chloro-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid methyl ester; 1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 6-chloro-2,3-dihydro-2-oxo-, methyl ester; CAS 1190312-76-5
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrrolo[2,3-B]Pyridine-4-Carboxylic Acid, 6-Chloro-2,3-Dihydro-2-Oxo-, Methyl Ester adheres to stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.