Description

1-(1-Amino-3-Phenylpropan-2-Yl)-4-(Trifluoromethyl)Piperidin-4-Ol Hcl is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core with a trifluoromethyl group. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting the central nervous system. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its unique trifluoromethylated piperidine scaffold.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the multi-step synthesis of complex APIs.
• Biochemical Research: Employed as a tool compound for probing biological pathways and enzyme interactions.
• Custom Synthesis: Basis for the contract manufacturing of specialized, high-value fine chemicals for clinical trials.

Basic Information

Product Name	1-(1-Amino-3-Phenylpropan-2-Yl)-4-(Trifluoromethyl)Piperidin-4-Ol Hydrochloride
CAS No.	1190009-29-0
Molecular Formula	C15H21F3N2O • HCl
Molecular Weight	338.80 g/mol (Free base: 302.34 g/mol)
Synonyms	4-(Trifluoromethyl)-1-[1-amino-3-phenyl-2-propanyl]-4-piperidinol hydrochloride; 1-(1-Amino-3-phenylpropan-2-yl)-4-(trifluoromethyl)piperidin-4-ol hydrochloride; 4-Piperidinol, 1-(1-amino-3-phenyl-2-propanyl)-4-(trifluoromethyl)-, hydrochloride; Trifluoromethylpiperidinol derivative HCl salt; CAS 1190009-29-0
EINECS	Contact for details

Quality Control

Our production of 1-(1-Amino-3-Phenylpropan-2-Yl)-4-(Trifluoromethyl)Piperidin-4-Ol Hcl adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with the high standards required for pharmaceutical R&D and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Assay (Titration)	97.0% - 102.0% (on anhydrous basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.