Description

6-Oxo-5-(Trifluoromethyl)-1,6-Dihydropyridine-3-Carboxylic Acid is a high-value trifluoromethyl-substituted pyridone derivative, serving as a critical advanced pharmaceutical intermediate. Its core value lies in enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. This compound is primarily needed by research institutions and pharmaceutical manufacturers focused on developing next-generation therapeutics, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel small-molecule drug candidates, especially those targeting kinase inhibition.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the trifluoromethyl group's influence on biological activity and environmental persistence.
• Material Science Precursor: Serves as a specialty monomer or ligand in the synthesis of advanced functional materials and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a probe molecule in biochemical assays.
• Contract Research & Development (CRO/CMO): Supplied to organizations engaged in custom synthesis and process development for client projects.
• Academic Research: Employed in university and institutional labs for fundamental studies in heterocyclic and fluorine chemistry.

Basic Information

Product Name	6-Oxo-5-(Trifluoromethyl)-1,6-Dihydropyridine-3-Carboxylic Acid
CAS No.	1189757-60-5
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	5-(Trifluoromethyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 1,6-dihydro-5-(trifluoromethyl)-6-oxo-; 5-(Trifluoromethyl)-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid; 1,6-Dihydro-5-(trifluoromethyl)-6-oxo-3-pyridinecarboxylic Acid; 6-Hydroxy-5-(trifluoromethyl)nicotinic acid; 6-Oxo-5-trifluoromethyl-1,6-dihydropyridine-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 6-Oxo-5-(Trifluoromethyl)-1,6-Dihydropyridine-3-Carboxylic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.