Description

{[4-(Trifluoromethyl)Phenyl]Phenylmethyl}Piperazine 2Hcl is a high-purity, advanced pharmaceutical intermediate characterized by its specific piperazine-based structure. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. Pharmaceutical R&D teams and fine chemical manufacturers need this material to develop and scale up next-generation therapeutic candidates with enhanced efficacy and selectivity.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, especially in neurological and psychiatric therapeutic areas.
• Chemical Synthesis Building Block: Used in organic synthesis for constructing complex molecules featuring the trifluoromethylphenyl pharmacophore, known to enhance metabolic stability and bioavailability.
• Research & Development (R&D): Essential for medicinal chemistry research in academic institutions and pharmaceutical companies for structure-activity relationship (SAR) studies.
• Scale-up and Process Chemistry: Employed in pilot plant and commercial-scale manufacturing of target APIs, requiring consistent high purity and reliable supply.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Item	Detail
Product Name	{[4-(Trifluoromethyl)Phenyl]Phenylmethyl}Piperazine 2Hcl
CAS No.	1189493-88-6
Molecular Formula	C18H19F3N2 • 2HCl
Molecular Weight	405.27 g/mol (Free base: 312.35 g/mol)
Synonyms	1-[(4-Trifluoromethylphenyl)phenylmethyl]piperazine dihydrochloride; 1-[(4-Trifluoromethylphenyl)(phenyl)methyl]piperazine hydrochloride (1:2); 1-(Bis(4-(trifluoromethyl)phenyl)methyl)piperazine dihydrochloride (related); 1-[(α-Phenyl-4-(trifluoromethyl)benzyl)]piperazine dihydrochloride; 1-[(4-Trifluoromethyl)benzhydryl]piperazine 2HCl; 4-(Trifluoromethyl)benzhydryl piperazine dihydrochloride; (4-Trifluoromethylphenyl)(phenyl)methyl piperazine dihydrochloride
EINECS	Contact for details

Quality Control

Our {[4-(Trifluoromethyl)Phenyl]Phenylmethyl}Piperazine 2Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.