Description

tert-Butyl 4-tert-Butyl-3-Hydroxypiperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine core with tert-butyl and hydroxyl functional groups. This compound matters as a critical building block for medicinal chemists, enabling the synthesis of complex molecules with enhanced pharmacokinetic properties. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating new active ingredients and fine-tuning drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Agrochemical Synthesis: Used as a precursor for developing advanced crop protection agents and herbicides.
• Chemical Research & Development: Serves as a versatile scaffold for exploring new chemical entities and structure-activity relationships (SAR).
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	tert-Butyl 4-tert-Butyl-3-Hydroxypiperidine-1-Carboxylate
CAS No.	1188265-71-5
Molecular Formula	C14H27NO3
Molecular Weight	257.37 g/mol
Synonyms	1-Boc-4-tert-butyl-3-hydroxypiperidine; 1-(tert-Butoxycarbonyl)-4-tert-butyl-3-hydroxypiperidine; 4-tert-Butyl-3-hydroxypiperidine-1-carboxylic acid tert-butyl ester; 3-Hydroxy-4-(tert-butyl)piperidine-1-carboxylic acid tert-butyl ester; 1-N-Boc-4-tert-butyl-3-hydroxypiperidine; tert-Butyl 4-(tert-butyl)-3-hydroxypiperidine-1-carboxylate; 1188265-71-5; Boc-4-tert-butyl-3-hydroxypiperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-tert-Butyl-3-Hydroxypiperidine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with each shipment, detailing all critical quality attributes. We are committed to meeting the stringent requirements of pharmaceutical development and can support custom purity specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.