Description

tert-Butyl 4-Ethyl-3-Hydroxypiperidine-1-Carboxylate is a high-purity, protected piperidine derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a versatile scaffold for constructing complex molecules with precise stereochemistry, essential for developing active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions and pharmaceutical manufacturers focused on the discovery and production of novel therapeutics, including central nervous system (CNS) agents and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly in medicinal chemistry programs.
• API Development: Used in the research and process development of new Active Pharmaceutical Ingredients (APIs), leveraging its piperidine core and protected amine functionality.
• Asymmetric Synthesis: Serves as a valuable starting material or intermediate in asymmetric catalytic reactions to introduce stereogenic centers.
• Chemical Biology & Proteomics: Can be utilized as a building block for creating molecular probes, enzyme inhibitors, or ligands for biological target studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.
• Academic & Industrial R&D: Employed in research laboratories for methodological development and exploring new synthetic routes to heterocyclic compounds.

Basic Information

Product Name	tert-Butyl 4-Ethyl-3-Hydroxypiperidine-1-Carboxylate
CAS No.	1188264-81-4
Molecular Formula	C12H23NO3
Molecular Weight	229.32 g/mol
Synonyms	1-Boc-4-ethyl-3-hydroxypiperidine; 1-(tert-Butoxycarbonyl)-4-ethyl-3-hydroxypiperidine; 4-Ethyl-3-hydroxy-1-piperidinecarboxylic acid tert-butyl ester; 3-Hydroxy-4-ethylpiperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-ethyl-3-hydroxypiperidine-1-carboxylate; 1-N-Boc-4-ethyl-3-hydroxypiperidine; 4-Ethyl-3-hydroxypiperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Ethyl-3-Hydroxypiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.