Description

tert-Butyl 3-Hydroxy-4-Methylpiperidine-1-Carboxylate is a high-purity, protected piperidine derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a versatile, functionalized scaffold for constructing complex molecules with precise stereochemistry. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and antiviral therapeutics.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides where specific stereochemistry is required for biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Research: Employed in academic and industrial R&D for exploring new synthetic methodologies and constructing complex molecular architectures.
• Fine Chemical Production: Integral to the multi-step synthesis of specialty chemicals and high-value performance materials.

Basic Information

Product Name	tert-Butyl 3-Hydroxy-4-Methylpiperidine-1-Carboxylate
CAS No.	1188264-78-9
Molecular Formula	C12H23NO3
Molecular Weight	229.32 g/mol
Synonyms	1-Boc-3-Hydroxy-4-Methylpiperidine; 1-(tert-Butoxycarbonyl)-3-Hydroxy-4-Methylpiperidine; 4-Methyl-3-Hydroxypiperidine-1-Carboxylic Acid tert-Butyl Ester; tert-Butyl 4-Methyl-3-Hydroxypiperidine-1-Carboxylate; 3-Hydroxy-4-methylpiperidine-1-carboxylic acid tert-butyl ester; 1-Boc-4-methyl-3-piperidinol; 3-Hydroxy-4-methyl-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Hydroxy-4-Methylpiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical and chiral purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee consistent quality and traceability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.