Description

tert-Butyl 3-Bromo-5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a brominated imidazopyrazine core. This compound is of significant value for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical companies and contract research organizations (CROs) engaged in the discovery of new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of complex drug candidates, particularly those targeting kinase inhibition.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to explore new chemical space.
• API Development: Serves as a critical fragment in the construction of Active Pharmaceutical Ingredients (APIs) for preclinical and clinical development.
• Chemical Biology Probes: Utilized in the development of chemical probes to study specific biological pathways and protein functions.
• Custom Synthesis: Employed by custom synthesis laboratories for the preparation of bespoke compounds for client-specific research programs.
• Library Synthesis: A valuable input for generating focused screening libraries for high-throughput screening (HTS) against novel biological targets.

Basic Information

Product Name	tert-Butyl 3-Bromo-5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxylate
CAS No.	1188264-74-5
Molecular Formula	C11H16BrN3O2
Molecular Weight	302.17 g/mol
Synonyms	3-Bromo-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-7-carboxylic acid tert-butyl ester; 7-Boc-3-bromo-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine; tert-Butyl 3-bromo-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-7-carboxylate; 3-Bromo-7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine; 1188264-74-5; BOC-3-Bromo-5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Bromo-5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.