Description

3-[4-(Trifluoromethyl)Phenyl]-1,2-Oxazol-5-Ol is a high-value heterocyclic building block featuring a trifluoromethylphenyl-substituted isoxazole core. This compound is significant for its role as a versatile synthetic intermediate in advanced organic synthesis, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating compounds with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve lipophilicity and biological activity.
• Material Science: Serves as a building block for advanced organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters or charge transport materials.
• Ligand Synthesis: Utilized in the preparation of specialized ligands for catalysis in asymmetric synthesis and cross-coupling reactions.
• Fluorine Chemistry Studies: An important compound for academic and industrial research focused on the incorporation of fluorine atoms into complex molecules to modulate their properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke molecules for client projects.

Basic Information

Product Name	3-[4-(Trifluoromethyl)Phenyl]-1,2-Oxazol-5-Ol
CAS No.	1188228-02-5
Molecular Formula	C10H6F3NO2
Molecular Weight	229.16 g/mol
Synonyms	5-Hydroxy-3-[4-(trifluoromethyl)phenyl]-1,2-oxazole; 3-(4-Trifluoromethylphenyl)-5-isoxazolol; 3-(4-(Trifluoromethyl)phenyl)-1,2-oxazol-5-ol; 5-Hydroxy-3-(α,α,α-trifluoro-p-tolyl)isoxazole; 3-(p-Trifluoromethylphenyl)-5-hydroxyisoxazole; 1188228-02-5; 3-(4-Trifluoromethylphenyl)-5-hydroxy-1,2-oxazole
EINECS	Contact for details

Quality Control

Our 3-[4-(Trifluoromethyl)Phenyl]-1,2-Oxazol-5-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure compliance with exacting R&D and process chemistry standards. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee supply reliability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.