Description

3-Bromo-5,6,7,8-Tetrahydro-1,6-Naphthyridine Dihydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its halogenated, saturated naphthyridine core. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical companies and contract research organizations (CROs) engaged in drug discovery programs, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially for neurological targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its modifiable bromine substituent and bicyclic scaffold.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening (HTS) campaigns.
• Chemical Biology Probes: Serves as a starting material for developing tool compounds to study biological pathways and protein function.
• Process Chemistry Development: Used in scaling up synthetic routes for active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.

Basic Information

Product Name	3-Bromo-5,6,7,8-Tetrahydro-1,6-Naphthyridine Dihydrochloride
CAS No.	1187932-53-1
Molecular Formula	C8H10BrCl2N2
Molecular Weight	278.99 g/mol
Synonyms	3-Bromo-5,6,7,8-tetrahydro-1,6-naphthyridine dihydrochloride; 3-Bromo-1,2,3,4-tetrahydro-1,6-naphthyridine dihydrochloride; 3-Bromo-5,6,7,8-tetrahydro[1,6]naphthyridine dihydrochloride; 3-Bromo-1,2,3,4-tetrahydro[1,6]naphthyridine dihydrochloride; 1,6-Naphthyridine, 3-bromo-5,6,7,8-tetrahydro-, dihydrochloride; 3-Bromo-5,6,7,8-tetrahydro-1,6-naphthyridine HCl salt
EINECS	Contact for details

Quality Control

Our 3-Bromo-5,6,7,8-Tetrahydro-1,6-Naphthyridine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), residual solvents, and other critical parameters is provided with every shipment to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.