Description

(R)-1-Cbz-2-Isopropyl-Piperazine is a high-purity chiral piperazine derivative, a critical building block in modern pharmaceutical synthesis. Its value lies in its role as a key intermediate for constructing complex, biologically active molecules with high stereochemical fidelity. This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical and biotechnology industries, particularly for the development of new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research.
• Asymmetric Synthesis: Used as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Peptidomimetics & Protease Inhibitors: Serves as a core scaffold for designing peptidomimetic compounds and inhibitors targeting various enzymes.
• API Development: Integral to the research, development, and scale-up of new Active Pharmaceutical Ingredients (APIs) requiring the (R)-2-isopropylpiperazine motif.
• Chemical Biology Probes: Employed in the construction of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and contract research organizations (CROs/CMOs) specializing in complex organic molecules.

Basic Information

Product Name	(R)-1-Cbz-2-Isopropyl-Piperazine
CAS No.	1187931-71-0
Molecular Formula	C15H22N2O2
Molecular Weight	262.35 g/mol
Synonyms	(R)-1-Benzyloxycarbonyl-2-isopropylpiperazine; (R)-1-Carbobenzyloxy-2-isopropylpiperazine; (R)-N-Cbz-2-isopropylpiperazine; (R)-2-Isopropyl-1-(phenylmethoxy)carbonylpiperazine; (R)-1-[(Benzyloxy)carbonyl]-2-(propan-2-yl)piperazine; (R)-2-(1-Methylethyl)-1-[(phenylmethoxy)carbonyl]piperazine; (R)-Cbz-2-iPr-Piperazine
EINECS	Contact for details

Quality Control

Our (R)-1-Cbz-2-Isopropyl-Piperazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. We provide comprehensive analytical data including HPLC/GC purity, chiral purity (enantiomeric excess), and identity confirmation (NMR, IR, MS). Certificates of Analysis (COA) documenting all specifications are available for every batch. Our quality commitment aligns with the standards required for GMP intermediates and advanced research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.