Description

(S)-2-Trifluoromethyl-Piperazine is a high-value, chiral piperazine derivative distinguished by the presence of a trifluoromethyl group, which imparts unique physicochemical properties critical for advanced synthesis. This compound serves as a sophisticated building block in medicinal chemistry, where its structural features are leveraged to modulate the potency, metabolic stability, and bioavailability of target molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly within central nervous system (CNS) and oncology drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce fluorine-based bioisosteres.
• CNS Drug Development: Employed in creating compounds targeting neurological receptors and enzymes due to the lipophilicity and metabolic stability conferred by the trifluoromethyl group.
• Oncological Agent Synthesis: Incorporated into molecular scaffolds designed as kinase inhibitors or other targeted cancer therapies.
• Agrochemical Research: Potential intermediate in the development of advanced pesticides and herbicides requiring specific stereochemistry.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands used in asymmetric catalysis.

Basic Information

Product Name	(S)-2-Trifluoromethyl-Piperazine
CAS No.	1187931-35-6
Molecular Formula	C5H9F3N2
Molecular Weight	154.13 g/mol
Synonyms	(S)-2-(Trifluoromethyl)piperazine; (S)-Piperazine, 2-(trifluoromethyl)-; (2S)-2-(Trifluoromethyl)piperazine; (S)-2-Trifluoromethylpiperazine; (S)-α-(Trifluoromethyl)piperazine; (S)-1,4-Diazacyclohexane, 2-(trifluoromethyl)-; (S)-Hexahydropyrazine, 2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our (S)-2-Trifluoromethyl-Piperazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (assay), enantiomeric excess, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.