Description

(R)-2-Trifluoromethyl-Piperazine CAS NO 1187928-91-1 is a high-value, chiral piperazine derivative distinguished by the presence of a trifluoromethyl group at the 2-position. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, particularly for the development of novel pharmaceuticals and agrochemicals. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for creating enantiomerically pure active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and oncology drug candidates.
• Agrochemical Synthesis: Used in the production of advanced, enantiomerically pure pesticides and herbicides where the specific stereochemistry can influence biological activity and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to induce high enantioselectivity in chemical reactions.
• Chemical Biology & Proteomics: Employed as a building block for designing molecular probes and inhibitors to study biological pathways and enzyme functions.
• Material Science Research: Investigated as a monomer or functional component in the synthesis of specialty polymers with unique fluorinated properties.

Basic Information

Product Name	(R)-2-Trifluoromethyl-Piperazine
CAS No.	1187928-91-1
Molecular Formula	C5H9F3N2
Molecular Weight	154.13 g/mol
Synonyms	(R)-2-(Trifluoromethyl)piperazine; (R)-Piperazine, 2-(trifluoromethyl)-; (2R)-2-(Trifluoromethyl)piperazine; (R)-α-Trifluoromethylpiperazine; (R)-Tfm-Piperazine; (R)-2-CF3-Piperazine; (R)-1,4-Diazacyclohexane, 2-trifluoromethyl-
EINECS	Contact for details

Quality Control

Our (R)-2-Trifluoromethyl-Piperazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, NMR, and MS for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.