Description

Ethyl 5,6,7,8-Tetrahydro-[1,2,4]Triazolo[4,3-A]Pyrazine-3-Carboxylate Hydrochloride is a high-purity, pharmaceutically relevant heterocyclic building block and synthetic intermediate. This compound is of significant value in medicinal chemistry research and development, particularly for the synthesis of novel drug candidates targeting the central nervous system. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly those with triazolopyrazine scaffolds.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies for new therapeutic agents.
• CNS Drug Development: Serves as a precursor for compounds being investigated for neurological and psychiatric disorders.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery.
• Process Chemistry: Used in the scale-up and route development for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Academic Research: A valuable reagent for universities and research institutes studying heterocyclic chemistry and novel synthetic methodologies.

Basic Information

Product Name	Ethyl 5,6,7,8-Tetrahydro-[1,2,4]Triazolo[4,3-A]Pyrazine-3-Carboxylate Hydrochloride
CAS No.	1187830-58-5
Molecular Formula	C9H14ClN5O2
Molecular Weight	259.69 g/mol
Synonyms	Ethyl 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine-3-carboxylate hydrochloride; 1,2,4-Triazolo[4,3-a]pyrazine-3-carboxylic acid, 5,6,7,8-tetrahydro-, ethyl ester, hydrochloride; Ethyl 5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine-3-carboxylate HCl; UNII-9Q7W3B3Y7F; 9Q7W3B3Y7F; SCHEMBL21806227; AKOS040759626; BCP32833.
EINECS	Contact for details

Quality Control

Our Ethyl 5,6,7,8-Tetrahydro-[1,2,4]Triazolo[4,3-A]Pyrazine-3-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with research and pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.