Description

tert-Butyl 4-(3-Bromopyridin-2-yl)piperazine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core with a bromopyridine substituent. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting neurological receptors and kinases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its versatile piperazine scaffold.
• Chemical Synthesis: Serves as a versatile building block for constructing complex heterocyclic compounds through cross-coupling and functional group transformations.
• Active Pharmaceutical Ingredient (API) Development: Integral to the production route of potential APIs for therapeutic areas including psychiatry, neurology, and cancer.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of pharmaceutical compounds.

Basic Information

Product Name	tert-Butyl 4-(3-Bromopyridin-2-yl)piperazine-1-carboxylate
CAS No.	1187386-01-1
Molecular Formula	C14H20BrN3O2
Molecular Weight	342.23 g/mol
Synonyms	1-Boc-4-(3-bromopyridin-2-yl)piperazine; 2-(3-Bromopyridin-2-yl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-(3-bromo-2-pyridinyl)-1-piperazinecarboxylate; 1-(tert-Butoxycarbonyl)-4-(3-bromopyridin-2-yl)piperazine; 3-Bromo-2-(4-Boc-piperazin-1-yl)pyridine; Boc-4-(3-bromo-2-pyridyl)piperazine; 1187386-01-1
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(3-Bromopyridin-2-yl)piperazine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D and process development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.