Description

1-(tert-Butoxycarbonyl)-4-(3-Methoxybenzyl)Piperidine-4-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a piperidine scaffold with a tert-butoxycarbonyl (Boc) protecting group and a 3-methoxybenzyl substituent. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates targeting the central nervous system and other therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly those with piperidine-based pharmacophores.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns for developing new chemical entities (NCEs).
• CNS Drug Development: Employed in the research of potential therapeutics for neurological and psychiatric disorders due to its structural relevance.
• Custom Synthesis: Serves as a starting material for contract manufacturing organizations (CMOs) producing bespoke compounds for client projects.
• Protease Inhibitor Scaffolds: The carboxylic acid and protected amine functionalities make it a candidate for constructing protease inhibitor libraries.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	1-(tert-Butoxycarbonyl)-4-(3-Methoxybenzyl)Piperidine-4-Carboxylic Acid
CAS No.	1187172-02-6
Molecular Formula	C19H27NO5
Molecular Weight	349.42 g/mol
Synonyms	1-Boc-4-(3-Methoxybenzyl)piperidine-4-carboxylic acid; 4-(3-Methoxybenzyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-4-carboxylic acid; 1-N-Boc-4-(3-methoxybenzyl)isonipecotic acid; 4-Carboxy-4-(3-methoxybenzyl)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(3-methoxybenzyl)-4-carboxypiperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-(3-methoxybenzyl)-4-piperidinecarboxylic acid; Boc-4-(3-methoxybenzyl)piperidine-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-(tert-Butoxycarbonyl)-4-(3-Methoxybenzyl)Piperidine-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity (typically by HPLC), and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.