Description

2-(4-Bromo-2-Fluorophenyl)-6-Methoxypyridine is a high-purity, advanced pharmaceutical intermediate and organic building block of significant commercial and research interest. This compound is valued for its unique halogenated aromatic structure, which makes it a critical precursor in the synthesis of complex molecules, particularly in medicinal chemistry. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its halogenated phenylpyridine scaffold.
• Material Science Precursor: Serves as a monomer or functional unit in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromo and fluoro substituents make it an excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Employed as a linker or warhead component in the design of novel bifunctional molecules for targeted protein degradation.
• Academic & Contract Research: Utilized in university and CRO laboratories for method development and exploring new synthetic pathways in organic chemistry.

Basic Information

Product Name	2-(4-Bromo-2-Fluorophenyl)-6-Methoxypyridine
CAS No.	1187170-02-0
Molecular Formula	C12H9BrFNO
Molecular Weight	282.11 g/mol
Synonyms	6-Methoxy-2-(4-bromo-2-fluorophenyl)pyridine; 2-(4-Bromo-2-fluorophenyl)-6-methoxypyridine; 4-Bromo-2-fluoro-2'-(6-methoxy)pyridine; 2-(4-Bromo-2-fluorophenyl)-6-pyridinol methyl ether; 6-Methoxy-2-(4-bromo-2-fluorophenyl)pyridine; 2-(4-Bromo-2-fluorophenyl)-6-methoxy-pyridine; 2-(4-Bromo-2-fluorophenyl)-6-methoxypyridine (CAS 1187170-02-0)
EINECS	Contact for details

Quality Control

Our 2-(4-Bromo-2-Fluorophenyl)-6-Methoxypyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP guidelines where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.