Description

4-Methyl-2-(4-Trifluoromethylbenzoyl)Pyridine is a high-purity, advanced pharmaceutical intermediate characterized by its distinct pyridine core substituted with a trifluoromethylbenzoyl group. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in areas requiring fluorinated compounds for improved drug efficacy.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the trifluoromethyl group contributes to biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for the synthesis of specialized ligands and fluorinated organic frameworks for catalytic and electronic applications.
• Chemical Biology Probes: Employed in the design of molecular probes and inhibitors for studying enzyme function and biological pathways.

Basic Information

Product Name	4-Methyl-2-(4-Trifluoromethylbenzoyl)Pyridine
CAS No.	1187165-26-9
Molecular Formula	C14H10F3NO
Molecular Weight	265.23 g/mol
Synonyms	2-(4-(Trifluoromethyl)benzoyl)-4-methylpyridine; 4-Methyl-2-[4-(trifluoromethyl)benzoyl]pyridine; 4-Methyl-2-(4-trifluoromethylbenzoyl)pyridine; 4-Methyl-2-(α,α,α-trifluoro-p-toluoyl)pyridine; 2-(4-Trifluoromethylbenzoyl)-4-picoline; 4-Methyl-2-(4-trifluoromethylbenzoyl)pyridine; 4-Methyl-2-(4-(trifluoromethyl)phenyl)carbonylpyridine
EINECS	Contact for details

Quality Control

Our 4-Methyl-2-(4-Trifluoromethylbenzoyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and batch-to-batch consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is light-sensitive (store away from light). Keep away from heat, sparks, and open flames. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.