Description

Methyl 4-Aminopiperidine-1-Carboxylate Hydrochloride is a high-purity piperidine derivative and a key protected intermediate in advanced organic synthesis. Its primary value lies in providing a reactive amine handle while offering stability and solubility advantages for complex molecule construction. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of drug candidates, especially those targeting central nervous system (CNS) disorders, pain management, and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel pesticides, herbicides, and fungicides where the piperidine scaffold is a key structural motif.
• Chemical Research & Development: Serves as a versatile synthon in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Employed in scale-up and route scouting for the efficient, cost-effective production of target molecules.
• Ligand and Catalyst Preparation: Useful for constructing chiral auxiliaries, ligands for asymmetric catalysis, and other specialty chemicals.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	Methyl 4-Aminopiperidine-1-Carboxylate Hydrochloride
CAS No.	1187160-88-8
Molecular Formula	C7H15ClN2O2
Molecular Weight	194.66 g/mol
Synonyms	1-Carbomethoxy-4-aminopiperidine hydrochloride; Methyl N-(4-aminopiperidin-1-yl)formimidate hydrochloride (tautomer); 4-Amino-1-piperidinecarboxylic acid methyl ester hydrochloride; 1-Piperidinecarboxylic acid, 4-amino-, methyl ester, hydrochloride; Methyl 4-aminopiperidine-1-carboxylate HCl; 4-Aminopiperidine-1-carboxylic acid methyl ester hydrochloride
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for all our fine chemical intermediates. Production of Methyl 4-Aminopiperidine-1-Carboxylate Hydrochloride adheres to current Good Manufacturing Practices (cGMP) where applicable, ensuring batch-to-batch consistency and reliability. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, verified by advanced analytical techniques including HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.