Description

tert-Butyl [(1S,3R,5S)-3-(3-Aminopyridin-4-yl)-5-methylcyclohexyl]carbamate is a high-purity, stereochemically defined chiral intermediate of significant importance in modern pharmaceutical synthesis. Its value lies in its complex, multifunctional structure, which serves as a critical building block for the development of novel active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and process development of new therapeutic agents, particularly within medicinal chemistry and process R&D departments.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Serves as a critical reference standard and starting material for scaling up and optimizing synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Asymmetric Synthesis: Utilized in the construction of stereogenic centers for the production of enantiomerically pure compounds.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and commercial APIs.

Basic Information

Product Name	tert-Butyl [(1S,3R,5S)-3-(3-Aminopyridin-4-yl)-5-methylcyclohexyl]carbamate
CAS No.	1187056-55-8
Molecular Formula	C17H27N3O2
Molecular Weight	305.42 g/mol
Synonyms	(1S,3R,5S)-3-(3-Amino-4-pyridinyl)-5-methylcyclohexyl carbamic acid 1,1-dimethylethyl ester; tert-Butyl N-[(1S,3R,5S)-3-(3-amino-4-pyridyl)-5-methyl-cyclohexyl]carbamate; Boc-Protected (1S,3R,5S)-3-(3-Aminopyridin-4-yl)-5-methylcyclohexylamine; (1S,3R,5S)-3-(3-Amino-4-pyridyl)-5-methylcyclohexyl tert-butylcarbamate; Boc-(1S,3R,5S)-3-(3-Amino-4-pyridinyl)-5-methylcyclohexylamine; CAS 1187056-55-8; Chiral Cyclohexyl-Pyridine Intermediate
EINECS	Contact for details

Quality Control

Our tert-Butyl [(1S,3R,5S)-3-(3-Aminopyridin-4-yl)-5-methylcyclohexyl]carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chiral purity and chemical identity, meeting the stringent requirements for pharmaceutical R&D and development. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Individual unknown impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.