Description

3-Chloro-5-(Hydroxymethyl)Picolinonitrile is a versatile and high-value heterocyclic building block characterized by its reactive nitrile and hydroxymethyl functional groups. This compound matters as a critical intermediate for synthesizing complex molecules in advanced pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists working on kinase inhibitors, novel active ingredients, and other fine chemical syntheses where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of kinase inhibitors and other small molecule active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators.
• Ligand Synthesis: Serves as a precursor for creating specialized ligands in catalysis and material science.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific projects.
• Academic Research: A valuable reagent for methodological development and novel heterocyclic chemistry in university laboratories.

Basic Information

Product Name	3-Chloro-5-(Hydroxymethyl)Picolinonitrile
CAS No.	1186637-82-0
Molecular Formula	C7H5ClN2O
Molecular Weight	168.58 g/mol
Synonyms	3-Chloro-5-(hydroxymethyl)pyridine-2-carbonitrile; 2-Pyridinecarbonitrile, 3-chloro-5-(hydroxymethyl)-; 3-Chloro-5-hydroxymethylpicolinonitrile; 3-Chloro-5-(hydroxymethyl)-2-cyanopyridine; 5-(Hydroxymethyl)-3-chloropicolinonitrile; 3-Chloro-5-(hydroxymethyl)-2-pyridinecarbonitrile
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-(Hydroxymethyl)Picolinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.