Description

1H-Pyrrolo[2,3-B]Pyridine, 2-Iodo-5-Nitro-1-(Phenylsulfonyl)- is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel pharmaceuticals and agrochemicals, enabling the construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical industries for lead optimization and scale-up activities.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of kinase inhibitors and other small-molecule drug candidates targeting various therapeutic areas.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products, leveraging its unique halogenated and nitrated pyrrolopyridine core.
• Material Science Precursor: Serves as a starting material for creating specialized organic ligands and functional molecules used in catalysis and electronic materials.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes for studying biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring this precise scaffold.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 2-Iodo-5-Nitro-1-(Phenylsulfonyl)-
CAS No.	1186501-78-9
Molecular Formula	C13H8IN3O4S
Molecular Weight	429.18 g/mol
Synonyms	2-Iodo-5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1-(Benzenesulfonyl)-2-iodo-5-nitro-1H-pyrrolo[2,3-b]pyridine; 2-Iodo-5-nitro-1-tosyl-1H-pyrrolo[2,3-b]pyridine (common alias); 1H-Pyrrolo[2,3-b]pyridine, 2-iodo-5-nitro-1-(phenylsulfonyl)-; 1186501-78-9; 2-Iodo-5-nitro-1H-pyrrolo[2,3-b]pyridine 1-(phenylsulfonyl) derivative; Nitro-iodo phenylsulfonyl pyrrolopyridine
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 2-Iodo-5-Nitro-1-(Phenylsulfonyl)- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.