Description

5-Bromo-3-((3-((tert-Butyldimethylsilyloxy)Methyl)Pyrrolidin-1-Yl)Methyl)-2-Chloropyridine is a sophisticated, multi-functional organic building block designed for advanced synthetic chemistry. Its molecular architecture, featuring halogenated pyridine and a protected pyrrolidine moiety, makes it a critical intermediate for constructing complex pharmacologically active molecules. This compound is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams focused on developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization due to its modifiable halogen and protected functional groups.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products.
• Chemical Biology: Employed as a probe or linker in the development of chemical tools for biological target identification and validation.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.
• Academic Research: Utilized in university and institutional labs for methodological development in heterocyclic and organosilicon chemistry.

Basic Information

Product Name	5-Bromo-3-((3-((tert-Butyldimethylsilyloxy)Methyl)Pyrrolidin-1-Yl)Methyl)-2-Chloropyridine
CAS No.	1186311-13-6
Molecular Formula	C17H28BrClN2OSi
Molecular Weight	419.86 g/mol
Synonyms	2-Chloro-5-bromo-3-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-pyrrolidinyl]methyl]pyridine; 5-Bromo-2-chloro-3-((3-((tert-butyldimethylsilyloxy)methyl)pyrrolidin-1-yl)methyl)pyridine; 2-Chloro-5-bromo-3-((3-((tert-butyldimethylsilyloxy)methyl)pyrrolidin-1-yl)methyl)pyridine; TBS-protected pyrrolidinylmethyl chlorobromopyridine; 1186311-13-6
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-((3-((tert-Butyldimethylsilyloxy)Methyl)Pyrrolidin-1-Yl)Methyl)-2-Chloropyridine is produced under strict quality management systems. Every batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency, meeting the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed HPLC, NMR, and mass spectrometry data are provided to guarantee full traceability and support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to exclude moisture and should be equilibrated to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.